A practical and scalable manufacturing process for an anti-fungal agent, Nikkomycin Z

A scalable and reliable manufacturing process for Nikkomycin Z HCl on a 170 g scale has been developed and optimized. The process is characterized by a 2.3 g/L fermentation yield, 79% purification yield, and >98% relative purity of the final product. This method is suitable for further scale up a...

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Bibliographic Details
Published inOrganic process research & development Vol. 17; no. 2; pp. 265 - 272
Main Authors Stenland, Christopher J, Lis, Lev G, Schendel, Frederick J, Hahn, Nicholas J, Smart, Mary A, Miller, Amy L, von Keitz, Marc G, Gurvich, Vadim J
Format Journal Article
LanguageEnglish
Published United States 15.02.2013
Subjects
Nikkomycin Z
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Summary:A scalable and reliable manufacturing process for Nikkomycin Z HCl on a 170 g scale has been developed and optimized. The process is characterized by a 2.3 g/L fermentation yield, 79% purification yield, and >98% relative purity of the final product. This method is suitable for further scale up and cGMP production. The Streptomyces tendae ΔNikQ strain developed during the course of this study is superior to any previously reported strain in terms of higher yield and purity of Nikkomycin Z.
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Biocee, Inc., Minneapolis, MN 55414
Present Addresses
Baxter Bioscience, Los Angeles, CA 90039
Syntiron, LLC, St. Paul, MN 55114
ISSN:1083-6160
DOI:10.1021/op3003294