Stopping antidepressants: withdrawal symptoms and rebound effects : Review and practical recommendations

• Published in: Nervenarzt Vol. 93; no. 1; p. 93
• Main Authors: Bschor, T, Bonnet, U, Pitzer, M, Baethge, C, Lieb, K, Gertz, H-J, Müller-Oerlinghausen, B
• Format: Journal Article
• Language: German
• Published: Germany 01.01.2022
• Subjects: Antidepressive Agents - adverse effects; Depression; Humans; Substance Withdrawal Syndrome - diagnosis; Rebound depression; Antidepressants/withdrawal; Chronic depression; Tapering of antidepressants; Antidepressants/discontinuation
• ISSN: 1433-0407
• DOI: 10.1007/s00115-021-01243-5

Stopping antidepressants can cause withdrawal (discontinuation) symptoms, the return of the original illness, and rebound. The latter means that the disease will return stronger, faster, or with greater likelihood than if it had not been treated with medication. The Psychiatry Working Group of the Drug Commission of the German Medical Association (AkdÄ) presents the scientific findings and provides practical recommendations for action. Withdrawal symptoms are multiform; unspecific physical symptoms are predominant. Distinguishing them from the recurrence of depressive symptoms can be difficult. Most of them are mild and self-limiting. There is insufficient evidence on the extent and frequency of rebound depression. The rebound risk implies that when establishing the medication, the short-term benefit must be weighed against the possible long-term risk of chronic depression or the possible need for long-term medication. Patients should be informed about the risk of withdrawal both as early as the joint decision-making process about treatment initiation and regularly during the course of treatment. Withdrawal should take place gradually, except in emergency situations, whereby small steps should be taken, especially in the low-dose range.