Targeted i 6 A-RNA degradation through sequential Fluorination-Azidation and Click reaction with imidazole-based probes

• Published in: Bioorganic & medicinal chemistry letters p. 129815
• Main Authors: Guo, Yuyang, Chen, Xiaoqian, Gan, Youfang, Li, Yuanyuan, Wang, Rui
• Format: Journal Article
• Language: English
• Published: England 01.08.2024

We report the use of trimethylsilyl azide and Selectfluor to implement a standard protocol targeted at the prenylated nucleic acid known as i A-RNA. After optimizing the conditions, we applied this method to regulate a wide range of i A-RNA species using synthetic imidazole-based probes (I-IV). We o...