Targeted i 6 A-RNA degradation through sequential Fluorination-Azidation and Click reaction with imidazole-based probes

We report the use of trimethylsilyl azide and Selectfluor to implement a standard protocol targeted at the prenylated nucleic acid known as i A-RNA. After optimizing the conditions, we applied this method to regulate a wide range of i A-RNA species using synthetic imidazole-based probes (I-IV). We o...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters p. 129815
Main Authors Guo, Yuyang, Chen, Xiaoqian, Gan, Youfang, Li, Yuanyuan, Wang, Rui
Format Journal Article
LanguageEnglish
Published England 01.08.2024
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Summary:We report the use of trimethylsilyl azide and Selectfluor to implement a standard protocol targeted at the prenylated nucleic acid known as i A-RNA. After optimizing the conditions, we applied this method to regulate a wide range of i A-RNA species using synthetic imidazole-based probes (I-IV). We observed that prenylated nucleic acid plays a crucial role in the cell hemostasis in A549 cell lines.
ISSN:1464-3405
DOI:10.1016/j.bmcl.2024.129815