Development of movement disorders in DBA/2J male mice under repeated experience of aggression

• Published in: Zurnal vyss̆ej nervnoj dejatelnosti imeni I P Pavlova Vol. 63; no. 2; p. 235
• Main Authors: Vishnivetskaia, G B, Avgustinovich, D F, Kudriavtseva, N N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.03.2013
• Subjects: Aggression - physiology; Animals; Behavior, Animal - physiology; Humans; Learning - physiology; Male; Maze Learning; Mice; Movement Disorders - physiopathology
• ISSN: 0044-4677
• DOI: 10.7868/S004446771302010X

Changes in the behavior of DBA/2J mice after gaining repeated experience of aggression have been investigated. It was shown that the long-term experience of aggression led to development of hyperactivity estimated as increased motor activity in different tests: open field, elevated plus maze and during testing of reaction to a novelty. Symptoms of attention deficit estimated in the "partition" test as a reduction of the communicativeness and the lack of reaction to unfamiliar partner were noticed. Appearance of a large number of hyperkinesis manifested most often in the form of sudden involuntary head movements (jerks) was observed in the behavior of aggressive males during agonistic interactions. Most of the changes in the behavior of DBA/2J mice differed significantly from previously detected in the behavior of aggressive mice of C57BL/6J and CBA/Lac strains, suggesting a significant contribution of heredity that determines the features of behavioral disorders that occur under the influence of long-term experience of aggression. Similarity of symptomatics of movement disturbances in mice and in humans with some neurological diseases is discussed.