Effects of tannic acid on growth performance, relative organ weight, antioxidative status, and intestinal histomorphology in broilers exposed to aflatoxin B 1

• Published in: Frontiers in veterinary science Vol. 9; p. 1037046
• Main Authors: Xi, Yu, Chen, Jing, Guo, Shuangshuang, Wang, Sitian, Liu, Zhipeng, Zheng, Liyun, Qi, Ya, Xu, Pengtao, Li, Lanlan, Zhang, Zhengfan, Ding, Binying
• Format: Journal Article
• Language: English
• Published: Switzerland 21.10.2022
• Subjects: Aflatoxin B1; growth performance; tannic acid; intestinal health; antioxidant capacity; broiler
• ISSN: 2297-1769; 2297-1769
• DOI: 10.3389/fvets.2022.1037046

A total of 480 one-day-old AA broiler chicks were randomly allocated to one of four treatments in a 2 × 2 factorial to investigate the effects of tannic acid (TA) on growth performance, relative organ weight, antioxidant capacity, and intestinal health in broilers dietary exposed to aflatoxin B (AFB ). Treatments were as follows: (1) CON, control diet; (2) TA, CON + 250 mg/kg TA; (3) AFB , CON + 500 μg/kg AFB ; and (4) TA+AFB , CON + 250 mg/kg TA + 500 μg/kg AFB . There were 10 replicate pens with 12 broilers per replicate. Dietary AFB challenge increased the feed conversion ratio during days 1 to 21 ( < 0.05). The TA in the diet did not show significant effects on the growth performance of broilers during the whole experiment period ( > 0.05). The liver and kidney relative weight was increased in the AF challenge groups compared with the CON ( < 0.05). The addition of TA could alleviate the relative weight increase of liver and kidney caused by AFB ( < 0.05). Broilers fed the AFB diets had lower activity of glutathione peroxidase, catalase, total superoxide dismutase, S-transferase, and total antioxidant capacity in plasma, liver and jejunum, and greater malondialdehyde content ( < 0.05). Dietary supplemented with 250 mg/kg TA increased the activities of antioxidative enzymes, and decreased malondialdehyde content ( < 0.05). In addition, AFB significantly reduced the villus height and crypt depth ratio in the ileum on day 42 ( < 0.05). In conclusion, supplementation with 250 mg/kg TA could partially protect the antioxidant capacity and prevent the enlargement of liver in broilers dietary challenged with 500 μg/kg AFB .