Paired-like repression/activation in pituitary development

Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/R...

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Bibliographic Details
Published inRecent progress in hormone research Vol. 58; p. 249
Main Authors Olson, Lorin E, Dasen, Jeremy S, Ju, Bong Gun, Tollkuhn, Jessica, Rosenfeld, Michael G
Format Journal Article
LanguageEnglish
Published United States 2003
Subjects
Animals
Basic Helix-Loop-Helix Transcription Factors
Homeodomain Proteins - genetics
Homeodomain Proteins - physiology
Humans
Mutation
Organogenesis
Pituitary Gland - embryology
Pituitary Gland - growth & development
Transcription Factor HES-1
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Summary:Pituitary gland development is controlled by signals that guide expression of specific combinations of transcription factors that dictate serial determination and differentiation events. One class of factors is paired-like homeodomain factors. Two that have been investigated are the repressor Hex1/Rpx and activator prophet of Pit-1 (Prop-1), which exert selective roles during pituitary development. The opposing actions of these factors provide one aspect of pituitary organogenesis.
ISSN:0079-9963
2374-7366
DOI:10.1210/rp.58.1.249