Acute renal failure due to thrombotic microangiopathy associated with Castleman's disease

We report a case of a 30-year-old man presenting with abdominal pain, fever, homodynamic instability, hepatosplenomegaly, acute renal failure, cervical lymph nodes, anaemia and thrombocytopenia. The patient was treated with empiric antibiotics, high dose corticosteroids, gammaglobulins, noradrenalin...

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Published inAnales de medicina interna (Madrid, Spain : 1984) Vol. 24; no. 12; p. 591
Main Authors López Montes, A, Andrés Mompeán, E, Martínez Villaescusa, M, Llamas Fuente, F, García-Mauriño Guelbenzu, M L
Format Journal Article
LanguageSpanish
Published Spain 01.12.2007
Subjects
Acute Kidney Injury - etiology
Adult
Castleman Disease - complications
Humans
Male
Thrombosis - complications
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Summary:We report a case of a 30-year-old man presenting with abdominal pain, fever, homodynamic instability, hepatosplenomegaly, acute renal failure, cervical lymph nodes, anaemia and thrombocytopenia. The patient was treated with empiric antibiotics, high dose corticosteroids, gammaglobulins, noradrenalin and diary intermittent haemodialysis, with an excellent response. The renal biopsy showed a thrombotic microangiopathy, the lymph node biopsy showed a Castleman s disease. Castleman s disease (also known as giant lymph node hyperplasia or angiofollicular lymph node hyperplasia) is a clinicopathological entity of unknown aetiology. A number of renal alterations have been described in association with the Castleman s disease.
ISSN:0212-7199