Acute hepatic failure after ingestion of mushrooms
This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. Af...
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| Published in | Der Internist (Berlin) Vol. 53; no. 5; p. 619 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | German |
| Published |
Germany
01.05.2012
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| Subjects | |
| Online Access | Get full text |
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| Abstract | This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. After quantitative determination of the Amanita toxins the patients were immediately transferred to a university hospital.Poisoning by the death cap mushroom is responsible for acute hepatic and often also renal failure and is accompanied by a high mortality. Clinical symptoms follow a three-phase course with gastrointestinal complaints, an asymptomatic interval and finally the hepatorenal phase. Even in suspected cases of intoxication, treatment should be started by antidote therapy with silibinin. |
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| AbstractList | This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. After quantitative determination of the Amanita toxins the patients were immediately transferred to a university hospital.Poisoning by the death cap mushroom is responsible for acute hepatic and often also renal failure and is accompanied by a high mortality. Clinical symptoms follow a three-phase course with gastrointestinal complaints, an asymptomatic interval and finally the hepatorenal phase. Even in suspected cases of intoxication, treatment should be started by antidote therapy with silibinin. |
| Author | Drewek-Platena, S Oeckinghaus, R Oeckinghaus, G S Cuneo, A Brockmeier, J Tebbe, U Götz, J Hochreuther, St |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22527661$$D View this record in MEDLINE/PubMed |
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| References | 9604278 - Toxicon. 1998 Jan;36(1):13-24 19730819 - Arch Toxicol. 2009 Dec;83(12 ):1091-6 20034036 - Hepatology. 2010 Jan;51(1):338-40 12475187 - J Toxicol Clin Toxicol. 2002;40(6):715-57 22114640 - Dtsch Arztebl Int. 2011 Oct;108(42):714-20 6291147 - Schweiz Med Wochenschr. 1982 Aug 21;112(34):1164-77 18946850 - Dtsch Med Wochenschr. 2008 Oct;133(44):2261-7 9118788 - Dtsch Med Wochenschr. 1997 Mar 21;122(12):351-5 13682210 - Dtsch Med Wochenschr. 1961 Jun 9;86:1121-7 |
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| SubjectTerms | Aged Amanita Antidotes - therapeutic use Antioxidants - therapeutic use Female Humans Male Mushroom Poisoning - diagnosis Mushroom Poisoning - drug therapy Mushroom Poisoning - etiology Silymarin - therapeutic use Treatment Outcome |
| Title | Acute hepatic failure after ingestion of mushrooms |
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