Acute hepatic failure after ingestion of mushrooms

This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. Af...

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Bibliographic Details
Published inDer Internist (Berlin) Vol. 53; no. 5; p. 619
Main Authors Oeckinghaus, R, Cuneo, A, Brockmeier, J, Oeckinghaus, G S, Drewek-Platena, S, Hochreuther, St, Götz, J, Tebbe, U
Format Journal Article
LanguageGerman
Published Germany 01.05.2012
Subjects
Aged
Amanita
Antidotes - therapeutic use
Antioxidants - therapeutic use
Female
Humans
Male
Mushroom Poisoning - diagnosis
Mushroom Poisoning - drug therapy
Mushroom Poisoning - etiology
Silymarin - therapeutic use
Treatment Outcome
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Summary:This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. After quantitative determination of the Amanita toxins the patients were immediately transferred to a university hospital.Poisoning by the death cap mushroom is responsible for acute hepatic and often also renal failure and is accompanied by a high mortality. Clinical symptoms follow a three-phase course with gastrointestinal complaints, an asymptomatic interval and finally the hepatorenal phase. Even in suspected cases of intoxication, treatment should be started by antidote therapy with silibinin.
ISSN:1432-1289
DOI:10.1007/s00108-011-3008-z