Acute lymphoblastic leukemia presenting without peripheral blasts but with osteolysis and hypercalcemia in an adolescent. Atypical but not rare

Joint pain is one of the major symptoms in early leukemia. We report on a 16-year-old girl who presented with groin pain and an osteolytic bone lesion. Acute lymphoblastic leukemia was diagnosed, but the laboratory workup and radiologic imaging revealed atypical results. Particularly in early precur...

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Bibliographic Details
Published inDer Orthopäde Vol. 38; no. 8; p. 752
Main Authors Karremann, M, Schreiner, U, Büsing, K-A, von Komorowski, G, Dürken, M
Format Journal Article
LanguageGerman
Published Germany 01.08.2009
Subjects
Adolescent
Blast Crisis - complications
Blast Crisis - diagnosis
Diagnosis, Differential
Female
Humans
Hypercalcemia - complications
Hypercalcemia - diagnosis
Osteolysis - complications
Osteolysis - diagnosis
Precursor Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis
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Summary:Joint pain is one of the major symptoms in early leukemia. We report on a 16-year-old girl who presented with groin pain and an osteolytic bone lesion. Acute lymphoblastic leukemia was diagnosed, but the laboratory workup and radiologic imaging revealed atypical results. Particularly in early precursor B-cell acute lymphoblastic leukemia, comparable initial symptoms and signs have been reported in adolescents; therefore, we recommend performing a bone marrow aspiration early on in cases of suspected osteolytic bone lesions.
ISSN:1433-0431
DOI:10.1007/s00132-009-1443-5