Malignant melanotic nerve sheath tumor of the posterior mediastinum

Melanotic schwannoma (MS) is a rare and infrequent subtype of schwannoma characterized by cytoplasmic deposits of melanosomes (melanin). Unlike the other schwannomas, it could have malignant transformation. Due to distinctive characteristics and atypical behavior from classic schwannomas subtypes, M...

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Published inMedicina Vol. 84; no. 2; p. 324
Main Authors Buero, Agustín, Olivera Lopez, Soledad B, Tchercansky, Ariel, Pankl, Leonardo G, Chimondeguy, Domingo J, Samudio, Mayra, Mendez, Julián, Lyons, Gustavo A
Format Journal Article
LanguageSpanish
Published Argentina 01.03.2024
Subjects
Adult
Female
Humans
Male
Mediastinal Neoplasms - diagnostic imaging
Mediastinal Neoplasms - pathology
Middle Aged
Nerve Sheath Neoplasms - diagnostic imaging
Nerve Sheath Neoplasms - pathology
Nerve Sheath Neoplasms - surgery
Neurilemmoma - diagnostic imaging
Neurilemmoma - pathology
Neurilemmoma - surgery
melanotic schwannoma
schwannoma
mediastinal tumors
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Summary:Melanotic schwannoma (MS) is a rare and infrequent subtype of schwannoma characterized by cytoplasmic deposits of melanosomes (melanin). Unlike the other schwannomas, it could have malignant transformation. Due to distinctive characteristics and atypical behavior from classic schwannomas subtypes, MS were renamed and reclassified as "melanocytic malignant neural sheath tumor" in the 5th ed. of the World Health Organization's classification of central nervous system tumors in 2021. We present two cases of MS that underwent complete surgical resection.
ISSN:1669-9106