Neonatal sepsis in the era of antenatal antibiotic prophylaxis

The aim of this study was to compare incidence, bacteriology and associated mortality of neonatal sepsis in a neonatal unit, after (2001-2004) and before (1995-1996) implementation of universal screening for prevention of Group B Streptococcus diseases. Early onset sepsis incidence decreased from 2....

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Bibliographic Details
Published inRevista chilena de infectología Vol. 24; no. 2; p. 111
Main Authors Tapia I, José Luis, Reichhard T, Cristina, Saldías R, M Isabel, Abarzúa C, Fernando, Pérez A, M Eugenia, González M, Alvaro, Gederlini G, Alessandra
Format Journal Article
LanguageSpanish
Published Chile 01.04.2007
Subjects
Antibiotic Prophylaxis
Chile - epidemiology
Female
Humans
Incidence
Infant, Newborn
Infectious Disease Transmission, Vertical - prevention & control
Infectious Disease Transmission, Vertical - statistics & numerical data
Intensive Care Units, Neonatal - statistics & numerical data
Male
Sepsis - microbiology
Sepsis - mortality
Sepsis - prevention & control
Chile
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Summary:The aim of this study was to compare incidence, bacteriology and associated mortality of neonatal sepsis in a neonatal unit, after (2001-2004) and before (1995-1996) implementation of universal screening for prevention of Group B Streptococcus diseases. Early onset sepsis incidence decreased from 2.5 to 1 per 1000 live births (p=0.03), with a decrease in the proportion of Group B Streptococcus cases from a 54% to 11% (p<0.01). In late onset sepsis, coagulase-negative Staphylococci continued to be the predominant pathogen (49% of cases), and Candida albicans emerged as the second etiologic agent in the postscreening period. Sepsis associated mortality was low in both periods (2.2%).
ISSN:0716-1018