Assessment of Brain Venous Structure in Military TBI Patients Using Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping

• Published in: Journal of neurotrauma
• Main Authors: Liu, Wei, Yeh, Ping-Hong, Nathan, Dominic, Song, Chihwa, Wu, Helena, Bonavia, Grant H, Ollinger, John M, Riedy, Gerard
• Format: Journal Article
• Language: English
• Published: United States 15.07.2019
• Subjects: VASCULAR INJURY; TRAUMATIC BRAIN INJURY; Susceptibility Weighted Imaging; MRI
• ISSN: 1557-9042
• DOI: 10.1089/neu.2018.5970

Brain venous volume above the lateral ventricle in military patients with TBI was assessed using two segmentation approaches on susceptibility weighted images (SWI) and quantitative susceptibility maps (QSM). This retrospective study included a total of 147 subjects: 14 patients with severe TBI; 38 patients with moderate TBI; 58 patients with mild TBI (28 with blast related injuries and 30 with nonblast related injuries) and 37 control subjects without history of TBI. Using the multiscale vessel enhancement filter on SWI images, patients with severe TBI demonstrated significantly higher segmented venous volumes compared to the controls. Using a threshold approach on QSM images, TBI patients with different severities all demonstrated increased segmented volumes compared to the control subjects: in the whole brain (severe, p = 0.001; moderate, p = 0.008; mild, p = 0.042 compared to controls), in the left hemisphere (severe, p = 0.01; moderate, p = 0.038 compared to controls), in the right hemisphere (severe, p = 0.001; moderate, p = 0.013; mild, p = 0.027 compared to controls). While segmented volumes on SWI appear to overlay directly on the visualized venous structures, the QSM derived segments also encompass some perivascular and deep white matter areas. This might represent the damage in the perivascular regions associated with iron deposition or astroglial scarring.