Variation in morphology or two entities?

A 37-year-old patient presented with B symptoms. On examination, hypodense liver lesions, multiple enlarged and partly confluent lymph nodes in the upper abdomen and retroperitoneum, as well as disseminated splenic and pulmonary foci were detected. Biopsies of a tumor in the coecum and the liver led...

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Bibliographic Details
Published inDer Pathologe Vol. 41; no. 1; p. 70
Main Authors Gerber, Tiemo S, Paschold, Markus, Lang, Hauke, Roth, Wilfried, Straub, Beate K
Format Journal Article
LanguageGerman
Published Germany 01.02.2020
Subjects
Adenocarcinoma - diagnosis
Adenocarcinoma - genetics
Adult
Colonic Neoplasms - diagnosis
Colonic Neoplasms - genetics
Humans
Liver Neoplasms - diagnosis
Liver Neoplasms - genetics
Microsatellite Instability
Neoadjuvant Therapy
Neoplasms, Second Primary - diagnosis
Neoplasms, Second Primary - genetics
Microstallite-instability
AFP
Metastasis
HNPCC-syndrome
Colon carcinoma
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Summary:A 37-year-old patient presented with B symptoms. On examination, hypodense liver lesions, multiple enlarged and partly confluent lymph nodes in the upper abdomen and retroperitoneum, as well as disseminated splenic and pulmonary foci were detected. Biopsies of a tumor in the coecum and the liver led to the diagnosis of an adenocarcinoma of the colon. In molecular pathology, microsatellite instability was detected. The post-neoadjuvant surgical specimen showed an unusual morphology and the question arose whether a second tumor should be considered.
ISSN:1432-1963
DOI:10.1007/s00292-019-00740-4