TPS-guided interstitial Iodine-125 implantation in patients with oral cavity and maxillofacial carcinomas

To investigate the efficacy as well as the complications involved in the use of interstitial Iodine-125 implantation for the treatment of oral cavity and maxillofacial carcinomas. Fifteen patients with oral cavity and maxillofacial carcinomas received treatment planning system (TPS)-guided interstit...

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Published inEuropean review for medical and pharmacological sciences Vol. 18; no. 19; p. 2803
Main Authors Meng, J, Zhang, J, Zhuang, Q-W, Wang, X, Li, Z-P, Gu, Q-P
Format Journal Article
LanguageEnglish
Published Italy 01.10.2014
Subjects
Adult
Aged
Aged, 80 and over
Brachytherapy - adverse effects
Brachytherapy - methods
Facial Neoplasms - pathology
Facial Neoplasms - radiotherapy
Female
Humans
Iodine Radioisotopes - administration & dosage
Lymphatic Metastasis
Male
Middle Aged
Mouth Neoplasms - pathology
Mouth Neoplasms - radiotherapy
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - radiotherapy
Radiotherapy Planning, Computer-Assisted - methods
Tomography, X-Ray Computed
Young Adult
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Summary:To investigate the efficacy as well as the complications involved in the use of interstitial Iodine-125 implantation for the treatment of oral cavity and maxillofacial carcinomas. Fifteen patients with oral cavity and maxillofacial carcinomas received treatment planning system (TPS)-guided interstitial Iodine-125 implantation. The apparent activity per particle ranged from 0.6 mCi (2.22MBq) to 0.7 mCi (2.59MBq). The matched peripheral dose delivered by radioactive seeds ranged from 90 to 120 Gy. The efficacy of the treatment and the postoperative complications were evaluated during follow-up. The seeds were implanted successfully in all 15 patients and median number of seeds implanted was 36.53. CT scans were performed in all patients at 1-6 months postoperatively. During follow-up at 6-27 months, seed migration occurred and a good local tumor control was achieved with an overall response of 86.7%. No severe side effects were observed. TPS-guided interstitial Iodine-125 implantation is an effective and safe procedure with minimal invasiveness for the treatment of oral cavity and maxillofacial carcinomas, and it effectively prevents the recurrence of cancer and short-term lymphatic metastasis.
ISSN:2284-0729