T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure
Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infec...
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Published in | Clinical infectious diseases |
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Main Authors | , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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United States
13.10.2023
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Abstract | Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status. |
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AbstractList | Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status. |
Author | Dubois, Melanie Netea, Mihai G Gray, Clive M Edlefsen, Paul T Cameron, Donald W Happel, Anna-Ursula Aitchison, John Seshadri, Chetan Mmasa, Nicholas Jaspan, Heather B Moyo, Sikhulile Gasper, Melanie A Iwase, Saori C Motsumi, Kessy Jao, Jennifer Duffy, Fergal Bhebhe, Lynnette Files, Megan A Schenkel, Sara Shao, Danica Powis, Kathleen M |
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Keywords | T-SPOT TB Botswana Southern Africa HIV exposure Infants Interferon-gamma release assay TB infection |
Language | English |
License | The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. |
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Title | T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure |
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