T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure

Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infec...

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Published inClinical infectious diseases
Main Authors Iwase, Saori C, Edlefsen, Paul T, Bhebhe, Lynnette, Motsumi, Kessy, Moyo, Sikhulile, Happel, Anna-Ursula, Shao, Danica, Mmasa, Nicholas, Schenkel, Sara, Gasper, Melanie A, Dubois, Melanie, Files, Megan A, Seshadri, Chetan, Duffy, Fergal, Aitchison, John, Netea, Mihai G, Jao, Jennifer, Cameron, Donald W, Gray, Clive M, Jaspan, Heather B, Powis, Kathleen M
Format Journal Article
LanguageEnglish
Published United States 13.10.2023
Subjects
T-SPOT TB
Botswana
Southern Africa
HIV exposure
Infants
Interferon-gamma release assay
TB infection
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Abstract Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.
AbstractList Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.
Author Dubois, Melanie
Netea, Mihai G
Gray, Clive M
Edlefsen, Paul T
Cameron, Donald W
Happel, Anna-Ursula
Aitchison, John
Seshadri, Chetan
Mmasa, Nicholas
Jaspan, Heather B
Moyo, Sikhulile
Gasper, Melanie A
Iwase, Saori C
Motsumi, Kessy
Jao, Jennifer
Duffy, Fergal
Bhebhe, Lynnette
Files, Megan A
Schenkel, Sara
Shao, Danica
Powis, Kathleen M
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  givenname: Saori C
  surname: Iwase
  fullname: Iwase, Saori C
  organization: Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 7925
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  givenname: Paul T
  surname: Edlefsen
  fullname: Edlefsen, Paul T
  organization: Fred Hutchinson Cancer Research Center, Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Seattle, United States, 98109
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  givenname: Lynnette
  surname: Bhebhe
  fullname: Bhebhe, Lynnette
  organization: Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana
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  givenname: Kessy
  surname: Motsumi
  fullname: Motsumi, Kessy
  organization: Botswana Harvard AIDS Institute Partnership, Gaborone, Botswana
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  givenname: Sikhulile
  surname: Moyo
  fullname: Moyo, Sikhulile
  organization: Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, United States, 02115
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  fullname: Happel, Anna-Ursula
  organization: Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa, 7925
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  givenname: Danica
  surname: Shao
  fullname: Shao, Danica
  organization: Fred Hutchinson Cancer Research Center, Statistical Center for HIV/AIDS Research and Prevention, Vaccine and Infectious Disease Division, Seattle, United States, 98109
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  givenname: Nicholas
  surname: Mmasa
  fullname: Mmasa, Nicholas
  organization: Surgical Department, County Durham and Darlington NHS Trust, Darlington Memorial Hospital, England, United Kingdom, DL3 6HX
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  givenname: Sara
  surname: Schenkel
  fullname: Schenkel, Sara
  organization: Department of Pediatric Global Health, Massachusetts General Hospital, Boston, United States, 02114
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  givenname: Melanie A
  surname: Gasper
  fullname: Gasper, Melanie A
  organization: Seattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, United States, 98109
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  givenname: Melanie
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  organization: Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Boston, United States, 02115
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  givenname: Megan A
  surname: Files
  fullname: Files, Megan A
  organization: Department of Medicine, University of Washington School of Medicine, Seattle, United States, 98195
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  givenname: Chetan
  surname: Seshadri
  fullname: Seshadri, Chetan
  organization: Department of Medicine, University of Washington School of Medicine, Seattle, United States, 98195
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  givenname: Fergal
  surname: Duffy
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  organization: Seattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, United States, 98109
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  givenname: John
  orcidid: 0000-0002-9153-6497
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  organization: Seattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, United States, 98109
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  givenname: Mihai G
  surname: Netea
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  organization: Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn, Bonn, Germany, 53113
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  organization: Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States, 60611
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  givenname: Donald W
  surname: Cameron
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  organization: Divisions of Infectious Diseases and Respirology, University of Ottawa at the Ottawa Hospital, Ottawa, Canada, K1N 1H3
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  givenname: Clive M
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  organization: Division of Molecular Biology and Human Genetics, Biomedical Research Institute, Stellenbosch University, Cape Town, South Africa, 7505
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  givenname: Heather B
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  organization: Seattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, United States, 98109
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  givenname: Kathleen M
  surname: Powis
  fullname: Powis, Kathleen M
  organization: Massachusetts General Hospital, Departments of Internal Medicine and Pediatrics, Boston, United States, 02114
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Keywords T-SPOT TB
Botswana
Southern Africa
HIV exposure
Infants
Interferon-gamma release assay
TB infection
Language English
License The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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