T-SPOT.TB reactivity in Southern African children with and without in utero HIV exposure

Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infec...

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Published inClinical infectious diseases
Main Authors Iwase, Saori C, Edlefsen, Paul T, Bhebhe, Lynnette, Motsumi, Kessy, Moyo, Sikhulile, Happel, Anna-Ursula, Shao, Danica, Mmasa, Nicholas, Schenkel, Sara, Gasper, Melanie A, Dubois, Melanie, Files, Megan A, Seshadri, Chetan, Duffy, Fergal, Aitchison, John, Netea, Mihai G, Jao, Jennifer, Cameron, Donald W, Gray, Clive M, Jaspan, Heather B, Powis, Kathleen M
Format Journal Article
LanguageEnglish
Published United States 13.10.2023
Subjects
T-SPOT TB
Botswana
Southern Africa
HIV exposure
Infants
Interferon-gamma release assay
TB infection
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Summary:Infants HIV-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared TB infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9-18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.
ISSN:1537-6591
DOI:10.1093/cid/ciad356