Pathology of the nipple-areola complex : I. Paget's disease of the nipple, variants, and differential diagnoses

The classical Paget's disease of the nipple is histologically characterized by tumor cell infiltration originating in intraductal or invasive breast carcinoma, immunohistologically by a frequent overexpression of HER2 and clinically by eczema-like changes of the nipple and areola. Variants with...

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Bibliographic Details
Published inDer Pathologe
Main Authors Streng, Agathe, Gutjahr, Ewgenija, Aulmann, Sebastian, Flechtenmacher, Christa, Toberer, Ferdinand, Heil, Jörg, Böcker, Werner, Sinn, Peter
Format Journal Article
LanguageGerman
Published Germany 01.07.2020
Subjects
Dermatoses of the nipple
Nipple eczema
Paget’s disease of the nipple
Toker cell hyperplasia
immunohistochemistry
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Summary:The classical Paget's disease of the nipple is histologically characterized by tumor cell infiltration originating in intraductal or invasive breast carcinoma, immunohistologically by a frequent overexpression of HER2 and clinically by eczema-like changes of the nipple and areola. Variants with different histological, immunohistological, and clinical features are observed in nonclassical forms of Paget's disease, such as isolated Paget's disease of the nipple, anaplastic Paget's disease, Paget's disease with invasion, and pigmented Paget's disease of the nipple. In the differential diagnosis of Paget's disease, benign changes have to be considered, including Toker cell hyperplasia, nipple eczema, and rare dermatoses.
ISSN:1432-1963
DOI:10.1007/s00292-020-00772-1