Extracellular vesicles and metabolic diseases: Dangerous liaisons

Extracellular vesicles (EVs) correspond to a heterogeneous set of membrane nanovesicles secreted in the extracellular medium and circulating in the various fluids of the body. These EVs convey biological material (proteins, lipids, nucleic acids) that they can transfer to target cells/tissues thus m...

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Bibliographic Details
Published inM.S. Médecine sciences Vol. 37; no. 12; p. 1125
Main Authors Blandin, Alexia, Le Lay, Soazig
Format Journal Article
LanguageFrench
Published France 20.12.2021
Subjects
Extracellular Vesicles
Humans
Metabolic Diseases
Obesity - complications
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Summary:Extracellular vesicles (EVs) correspond to a heterogeneous set of membrane nanovesicles secreted in the extracellular medium and circulating in the various fluids of the body. These EVs convey biological material (proteins, lipids, nucleic acids) that they can transfer to target cells/tissues thus modulating their response and/or phenotype. The metabolic dysfunctions characterizing metabolic diseases associated with obesity are associated with changes in circulating EV concentrations as well as alterations in their content. The growing interest in EVs as new vectors of intercellular communication has led to question about their role in the development of metabolic complications. In this review, we will discuss the literature on circulating EVs as potential markers of metabolic diseases and then detail inter-organ dialogue based on this EV trafficking underlying the development of related obesity. Finally, we will discuss future avenues of research that will help to better understand the link between EVs and metabolic diseases.
ISSN:1958-5381
DOI:10.1051/medsci/2021209