T reg cell-based therapies: challenges and perspectives

Cellular therapies using regulatory T (T ) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of T cells and describe new efforts in T cell engineering to enhance specific...

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Bibliographic Details
Published inNature reviews. Immunology Vol. 20; no. 3; p. 158
Main Authors Raffin, Caroline, Vo, Linda T, Bluestone, Jeffrey A
Format Journal Article
LanguageEnglish
Published England 01.03.2020
Subjects
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Cell- and Tissue-Based Therapy - methods
Graft Rejection - immunology
Graft Rejection - prevention & control
Humans
Immunotherapy, Adoptive - methods
T-Lymphocytes, Regulatory - immunology
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Summary:Cellular therapies using regulatory T (T ) cells are currently undergoing clinical trials for the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In this Review, we discuss the biology of T cells and describe new efforts in T cell engineering to enhance specificity, stability, functional activity and delivery. Finally, we envision that the success of T cell therapy in autoimmunity and transplantation will encourage the clinical use of adoptive T cell therapy for non-immune diseases, such as neurological disorders and tissue repair.
ISSN:1474-1741
DOI:10.1038/s41577-019-0232-6