Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. The Groupe d'Etude des Tumeurs a Calcitonine (GETC)

Combinations of 5-fluorouracil (5-FU) and streptozocin and 5-FU and dacarbazine were given alternately to 20 patients with metastatic medullary thyroid carcinoma. Three partial responses and 11 long-term stabilizations were observed. No unexpected toxicity occurred.

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Bibliographic Details
Published inBritish journal of cancer Vol. 71; no. 2; pp. 363 - 365
Main Authors Schlumberger, M, Abdelmoumene, N, Delisle, M J, Couette, J E
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.02.1995
Subjects
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Medullary - drug therapy
Carcinoma, Medullary - pathology
Carcinoma, Medullary - surgery
Combined Modality Therapy
Dacarbazine - administration & dosage
Drug Administration Schedule
Female
Fluorouracil - administration & dosage
Humans
Male
Middle Aged
Neoplasm Metastasis
Palliative Care
Radiotherapy, Adjuvant
Streptozocin - administration & dosage
Thyroid Neoplasms - drug therapy
Thyroid Neoplasms - pathology
Thyroid Neoplasms - radiotherapy
Thyroid Neoplasms - surgery
Thyroidectomy
Treatment Outcome
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Summary:Combinations of 5-fluorouracil (5-FU) and streptozocin and 5-FU and dacarbazine were given alternately to 20 patients with metastatic medullary thyroid carcinoma. Three partial responses and 11 long-term stabilizations were observed. No unexpected toxicity occurred.
ISSN:0007-0920
1532-1827