The detection of antigenemia in typhoid patients at different periods in the course of the infection

The enzyme immunoassay of serum samples, obtained from 37 typhoid patients and previously subjected to bacteriological study with negative results, permitted the detection of S. typhi specific antigens and, as a consequence, the rapid diagnosis of the disease. The prevalence of various antigenic com...

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Bibliographic Details
Published inŽurnal mikrobiologii, ėpidemiologii i immunobiologii no. 12; p. 33
Main Authors Gorelov, A L, Levina, G A, Prozorovskiĭ, S V
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.12.1989
Subjects
Acute Disease
Antigens, Bacterial - analysis
Carrier State - immunology
Convalescence
Enzyme-Linked Immunosorbent Assay
Humans
L Forms - immunology
O Antigens
Polysaccharides, Bacterial
Salmonella typhi - immunology
Time Factors
Typhoid Fever - immunology
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Summary:The enzyme immunoassay of serum samples, obtained from 37 typhoid patients and previously subjected to bacteriological study with negative results, permitted the detection of S. typhi specific antigens and, as a consequence, the rapid diagnosis of the disease. The prevalence of various antigenic components of S. typhi was observed at different stages of infection. The presence of surface O and Vi antigens was characteristic of acute stages of S. typhi infection. At the same time L-form antigens, in rare cases in combination with surface O and Vi antigens, were characteristic of patients at the period following the acute stage of the disease, as well as chronic carriers. This is indicative of the necessity of introducing specific antibodies to the antigenic determinants of S. typhi L forms into the assortment of diagnostic immune preparations.
ISSN:0372-9311