Cyclic neutropenia: a disease or a syndrome?

Peripheral blood and bone marrow morphology, blood and bone marrow lymphocyte subpopulation composition were studied in two children with cyclic neutropenia, using flow cytofluorometry, monoclonal antibodies, colony-forming capacity of granulocytic macrophagal precursors in semi-fluid agar. The stud...

Full description

Saved in:
Bibliographic Details
Published inGematologiia i transfuziologiia Vol. 37; no. 9-10; p. 9
Main Authors Polovtseva, T V, Nefedova, E V, Porkhovatyĭ, S Ia, Finogenova, N A, Man'ko, V M, Khakhalin, L N, Shereshkov, S I
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.09.1992
Subjects
Adolescent
Bone Marrow - pathology
Child
Colony-Forming Units Assay - methods
Female
Flow Cytometry - methods
Hematopoietic Stem Cells - pathology
Humans
Leukocyte Count
Male
Neutropenia - blood
Neutropenia - diagnosis
Neutropenia - etiology
Neutropenia - pathology
Neutrophils - pathology
Periodicity
Recurrence
Syndrome
Time Factors
Online AccessGet more information

Cover

More Information
Summary:Peripheral blood and bone marrow morphology, blood and bone marrow lymphocyte subpopulation composition were studied in two children with cyclic neutropenia, using flow cytofluorometry, monoclonal antibodies, colony-forming capacity of granulocytic macrophagal precursors in semi-fluid agar. The studies were conducted in varying periods of the neutropenic cycle. Differences were revealed in immunohematologic parameters and clinical course of neutropenia in the two patients. The analysis of the literature data and the authors' own observations of the patients with cyclic neutropenia permitted a suggestion on high heterogeneity of pathogenetic mechanisms of this disease.
ISSN:0234-5730