Is the risk of pneumocystosis predictable in Wegener's disease?

Twelve cases of Pneumocystis pneumonia in patients with Wegener's granulomatosis were compared with a control-group of 32 patients. Our study showed that the dose of cyclophosphamide received in the first three months and a profound lymphocytopenia were strongly predictive of a risk of Pneumocy...

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Bibliographic Details
Published inLa revue de medecine interne Vol. 14; no. 10; p. 1025
Main Authors Godeau, B, Mainardi, J L, Hachulla, E, Guillevin, L, Roudot-Thoraval, F, Remy, P, Huong-Boutin, L T, Schaeffer, A, Piette, J C
Format Journal Article
LanguageFrench
Published France 1993
Subjects
Cyclophosphamide - adverse effects
Granulomatosis with Polyangiitis - complications
Humans
Lymphopenia - chemically induced
Pneumonia, Pneumocystis - etiology
Pneumonia, Pneumocystis - prevention & control
Retrospective Studies
Risk Factors
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Summary:Twelve cases of Pneumocystis pneumonia in patients with Wegener's granulomatosis were compared with a control-group of 32 patients. Our study showed that the dose of cyclophosphamide received in the first three months and a profound lymphocytopenia were strongly predictive of a risk of Pneumocystis carinii pneumonia in these patients.
ISSN:0248-8663
DOI:10.1016/S0248-8663(05)80142-0