Increased neutrophil leukocyte chemotaxis induced by release of a serum factor in toluene-diisocyanate (TDI) asthma

The activation of blood neutrophil leukocytes has been proven in subjects with IgE-mediated and non-IgE-mediated asthma. This event appears to be modulated by the release of humoral factors. We submitted 12 toluene-diisocyanate (TDI) asthmatic workers to TDI provocation. During the late asthmatic re...

Full description

Saved in:
Bibliographic Details
Published inLung Vol. 166; no. 6; p. 317
Main Authors Valentino, M, Governa, M, Fiorini, R
Format Journal Article
LanguageEnglish
Published United States 01.11.1988
Subjects
Adult
Asthma - chemically induced
Asthma - immunology
Bronchial Provocation Tests
Chemotactic Factors - biosynthesis
Chemotaxis, Leukocyte - drug effects
Cyanates - adverse effects
Female
Humans
Interleukin-8
Male
Neutrophils - immunology
Occupational Diseases - chemically induced
Occupational Diseases - immunology
Toluene 2,4-Diisocyanate - adverse effects
Online AccessGet more information

Cover

More Information
Summary:The activation of blood neutrophil leukocytes has been proven in subjects with IgE-mediated and non-IgE-mediated asthma. This event appears to be modulated by the release of humoral factors. We submitted 12 toluene-diisocyanate (TDI) asthmatic workers to TDI provocation. During the late asthmatic reaction there was release of a serum chemoattracting factor for normal neutrophil leukocytes and activation of asthmatic neutrophil leukocytes. This appears to be the first demonstration of neutrophil chemotactic activity liberated during the late TDI reaction in humans. The results are explained by an acute inflammatory process occurring during the late asthmatic reaction induced by TDI.
ISSN:0341-2040
DOI:10.1007/BF02714064