Severe vasculitis in cryoglobulinemia--mechanisms of Fc gamma receptor activation of granulocytes
Monoclonal IgG-cryoglobulins activate PMN through Fc gamma-receptors. The expression of Fc gamma RII and Fc gamma RIII is decreased, the expression of Fc gamma RI, CD66 and CD67 is increased. During this activation substances like superoxide anions and lysosomal enzymes subsequently damaging the end...
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Published in | Immunitat und Infektion Vol. 19; no. 3; p. 87 |
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Main Authors | , , |
Format | Journal Article |
Language | German |
Published |
Germany
01.06.1991
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Abstract | Monoclonal IgG-cryoglobulins activate PMN through Fc gamma-receptors. The expression of Fc gamma RII and Fc gamma RIII is decreased, the expression of Fc gamma RI, CD66 and CD67 is increased. During this activation substances like superoxide anions and lysosomal enzymes subsequently damaging the endothelium are released. |
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AbstractList | Monoclonal IgG-cryoglobulins activate PMN through Fc gamma-receptors. The expression of Fc gamma RII and Fc gamma RIII is decreased, the expression of Fc gamma RI, CD66 and CD67 is increased. During this activation substances like superoxide anions and lysosomal enzymes subsequently damaging the endothelium are released. |
Author | Schmidt, R E Hundt, M Zielinska-Skowronek, M |
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DocumentTitleAlternate | Schwere Vaskulitis bei Kryoglobulinämie--Mechanismen der Fc gamma-Rezeptor-Aktivierung von Granulozyten |
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SubjectTerms | Adult Antigens, CD - immunology Antigens, Differentiation - immunology Cryoglobulinemia - complications Endothelium, Vascular - pathology Humans Male Neutrophils - immunology Receptors, Fc - immunology Receptors, IgG Vasculitis - etiology |
Title | Severe vasculitis in cryoglobulinemia--mechanisms of Fc gamma receptor activation of granulocytes |
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