Severe vasculitis in cryoglobulinemia--mechanisms of Fc gamma receptor activation of granulocytes

Monoclonal IgG-cryoglobulins activate PMN through Fc gamma-receptors. The expression of Fc gamma RII and Fc gamma RIII is decreased, the expression of Fc gamma RI, CD66 and CD67 is increased. During this activation substances like superoxide anions and lysosomal enzymes subsequently damaging the end...

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Bibliographic Details
Published inImmunitat und Infektion Vol. 19; no. 3; p. 87
Main Authors Hundt, M, Zielinska-Skowronek, M, Schmidt, R E
Format Journal Article
LanguageGerman
Published Germany 01.06.1991
Subjects
Adult
Antigens, CD - immunology
Antigens, Differentiation - immunology
Cryoglobulinemia - complications
Endothelium, Vascular - pathology
Humans
Male
Neutrophils - immunology
Receptors, Fc - immunology
Receptors, IgG
Vasculitis - etiology
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Summary:Monoclonal IgG-cryoglobulins activate PMN through Fc gamma-receptors. The expression of Fc gamma RII and Fc gamma RIII is decreased, the expression of Fc gamma RI, CD66 and CD67 is increased. During this activation substances like superoxide anions and lysosomal enzymes subsequently damaging the endothelium are released.