An interpretable and transparent machine learning framework for appendicitis detection in pediatric patients

• Published in: Scientific reports Vol. 14; no. 1; p. 24454
• Main Authors: Chadaga, Krishnaraj, Khanna, Varada, Prabhu, Srikanth, Sampathila, Niranjana, Chadaga, Rajagopala, Umakanth, Shashikiran, Bhat, Devadas, Swathi, K. S., Kamath, Radhika
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.10.2024; Nature Publishing Group
• Subjects: 639/166/985; 639/705/1042; 692/499; 692/53/2421; 692/53/2423; Algorithms; Appendicitis; Appendix; Artificial intelligence; Bayesian analysis; Humanities and Social Sciences; Learning algorithms; Leukocytes; Machine learning; multidisciplinary; Patients; Pediatrics; Peritonitis; Science; Science (multidisciplinary); Sepsis
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-75896-y

Appendicitis, an infection and inflammation of the appendix is a prevalent condition in children that requires immediate treatment. Rupture of the appendix may lead to several complications, such as peritonitis and sepsis. Appendicitis is medically diagnosed using urine, blood, and imaging tests. In recent times, Artificial Intelligence and machine learning have been a boon for medicine. Hence, several supervised learning techniques have been utilized in this research to diagnose appendicitis in pediatric patients. Six heterogeneous searching techniques have been used to perform hyperparameter tuning and optimize predictions. These are Bayesian Optimization, Hybrid Bat Algorithm, Hybrid Self-adaptive Bat Algorithm, Firefly Algorithm, Grid Search, and Randomized Search. Further, nine classification metrics were utilized in this study. The Hybrid Bat Algorithm technique performed the best among the above algorithms, with an accuracy of 94% for the customized APPSTACK model. Five explainable artificial intelligence techniques have been tested to interpret the results made by the classifiers. According to the explainers, length of stay, means vermiform appendix detected on ultrasonography, white blood cells, and appendix diameter were the most crucial markers in detecting appendicitis. The proposed system can be used in hospitals for an early/quick diagnosis and to validate the results obtained by other diagnostic modalities.