NONENDOSCOPIC DETECTION OF BARRETT'S ESOPHAGUS IN PATIENTS WITHOUT GERD SYMPTOMS

• Published in: The American journal of gastroenterology
• Main Authors: Chak, Amitabh, Keerthy, Komal, Wang, Gi-Ming, Brock, Wendy, Bednarchik, Beth, Guptha, Rajesh, Verma, Suman, Moinova, Helen, Tatsuoka, Curtis, Dumot, John, Thomas, Sapna, Willis, Joseph E, Markowitz, Sanford
• Format: Journal Article
• Language: English
• Published: 01.08.2025
• ISSN: 1572-0241; 1572-0241
• DOI: 10.14309/ajg.0000000000003669

Upper endoscopy (EGD) is generally recommended in those with chronic gastroesophageal reflux disease (GERD).BACKGROUNDUpper endoscopy (EGD) is generally recommended in those with chronic gastroesophageal reflux disease (GERD).To evaluate non-endoscopic screening in those without GERD symptoms.AIMTo evaluate non-endoscopic screening in those without GERD symptoms.EsoCheck/Esoguard (LucidDx) was performed in recruited patients without chronic GERD who had ≥3 other BE risk factors.METHODSEsoCheck/Esoguard (LucidDx) was performed in recruited patients without chronic GERD who had ≥3 other BE risk factors.The EsoGuard assay was positive in 34 of 120 patients. BE was identified in 9 of 27 who had follow-up EGD, PPV = 33% [17%, 54%]. EGD performed in 22 of 86 subjects with negative assays found no BE, NPV = 100% [85%, 100%].RESULTSThe EsoGuard assay was positive in 34 of 120 patients. BE was identified in 9 of 27 who had follow-up EGD, PPV = 33% [17%, 54%]. EGD performed in 22 of 86 subjects with negative assays found no BE, NPV = 100% [85%, 100%].Non-endoscopic BE detection is effective in patients without chronic GERD.CONCLUSIONNon-endoscopic BE detection is effective in patients without chronic GERD.