Human Heart Failure Alters Mitochondria and Fiber 3D Structure Triggering Metabolic Shifts

This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysre...

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Published inbioRxiv
Main Authors Vue, Zer, Ajayi, Peter T, Neikirk, Kit, Murphy, Alexandria, Prasad, Praveena, Jenkins, Brenita C, Vang, Larry, Garza-Lopez, Edgar, Mungai, Margaret, Marshall, Andrea G, Beasley, Heather K, Killion, Mason, Parker, Remi, Josephs Anukodem, Lavine, Kory, Ajijola, Olujimi, Mobley, Bret, Dao-Fu, Dai, Exil, Vernat, Kirabo, Annet, Su, Yan Ru, Tomasek, Kelsey, Zhang, Xiuqi, Wanjalla, Celestine N, Hubert, David L, Shao, Jianqiang, Phillips, Mark A, Mcreynolds, Melanie, Glancy, Brian, Hinton, Antentor
Format Paper
LanguageEnglish
Published Cold Spring Harbor Cold Spring Harbor Laboratory Press 14.12.2023
Subjects
Congestive heart failure
Metabolomics
Mitochondria
Myofibrils
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Summary:This study, utilizing SBF-SEM, reveals structural alterations in mitochondria and myofibrils in human heart failure (HF). Mitochondria in HF show changes in structure, while myofibrils exhibit increased cross-sectional area and branching. Metabolomic and lipidomic analyses indicate concomitant dysregulation in key pathways. The findings underscore the need for personalized treatments considering individualized structural changes in HF.Competing Interest StatementThe authors have declared no competing interest.Footnotes* Author list update
DOI:10.1101/2023.11.28.569095