Variations in fecal microbiota of first episode schizophrenia associated with clinical assessment and serum metabolomics

• Published in: Beijing da xue xue bao. Journal of Peking University. Yi xue ban Vol. 54; no. 5; pp. 863 - 873
• Main Authors: Wang, X P, Zhang, Y Y, Lu, T L, Lu, Z, Kang, Z W, Sun, Y Y, Yue, W H
• Format: Journal Article
• Language: Chinese
• Published: 18.10.2022
• ISSN: 1671-167X
• DOI: 10.19723/j.issn.1671-167X.2022.05.014

OBJECTIVETo explore the role of the microbiota in drug naïve first-onset schizophrenia patients and to seek evidence from multidimensional longitudinal analyses of the intestinal microbiome and clinical phenotype with antipsychotic drugs (APDs) therapy. METHODSIn this study, 28 drug naïve first onset schizophrenia patients and age-, gender- and education-matched 29 healthy controls were included, and the patients were treated with APDs. We collected fecal and serum samples at baseline and after 6 weeks of treatment to identify the different microbiota strains and analyse their correlation with clinical symptoms and serum metabolites. The 16S rRNA genes of the gut microbiota were sequenced, and the diversity and relative abundance at the phylum and genus levels were analyzsed in detail. The PANSS score, BMI changed value, and serum metabolome were included in the data analyses. RESULTSA multiomics study found a potential connection among the clinical phenotype, microbiota and metabolome. The species diversity