Reversion and Conversion of Interferon-[gamma] Release Assay Results in HIV-1-Infected Individuals

In this prospective study, human immunodeficiency virus type 1 (HIV-1 )-infected subjects underwent QuantiFERON-TB Gold In-Tube interferon-[gamma] release assay (IGRA) testing at baseline and after 24 months in a low tuberculosis incidence country. Concordant baseline and follow-up results were obse...

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Published inThe Journal of infectious diseases Vol. 209; no. 5; pp. 729 - 733
Main Authors Aichelburg, Maximilian C, Reiberger, Thomas, Breitenecker, Florian, Mandorfer, Mattias, Makristathis, Athanasios, Rieger, Armin
Format Journal Article
LanguageEnglish
Published 01.03.2014
Subjects
Human immunodeficiency virus 1
Mycobacterium
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Summary:In this prospective study, human immunodeficiency virus type 1 (HIV-1 )-infected subjects underwent QuantiFERON-TB Gold In-Tube interferon-[gamma] release assay (IGRA) testing at baseline and after 24 months in a low tuberculosis incidence country. Concordant baseline and follow-up results were observed in 86% (n = 686 of 794) of subjects. IGRA conversions occurred in 9% (n = 63 of 718), whereas IGRA reversions were seen in 33% (n = 25 of 76) of individuals. Of the 10 active tuberculosis cases during follow-up, 5 had concordant positive IGRA results and 2 were IGRA converters. Although the clinical significance of IGRA conversions and reversions remains to be established, repeated IGRA testing seems to be of value in HIV-1-infected individuals.
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ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/jit418