Application of thrombomodulin in treatment of sepsis

Sepsis is a clinical syndrome which results from severe infection and systemic inflammatory response. Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Thrombomodulin is an endogenous anticoagulant protein that possesses both anti-inflamma...

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Published inShanghai jiao tong da xue xue bao. Yi xue ban Vol. 33; no. 7; pp. 1039 - 1042
Main Authors Lu, H-X, Jia, Y-T, Yao, M, Fang, Y
Format Journal Article
LanguageChinese
Published 01.07.2013
Subjects
Anticoagulants
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Summary:Sepsis is a clinical syndrome which results from severe infection and systemic inflammatory response. Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Thrombomodulin is an endogenous anticoagulant protein that possesses both anti-inflammatory and anticoagulant properties in directly and indirectly ways, which provides a new choice for the treatment of sepsis. The structure, function and application of thrombomodulin in the treatment of sepsis are introduced in this paper.
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ISSN:1674-8115
DOI:10.3969/j.issn.1674-8115.2013.07.030