Magnetic resonance imaging of dissolved hyperpolarized (129)Xe using a membrane-based continuous flow system

A technique for continuous production of solutions containing hyperpolarized (129)Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized (129)Xe has been c...

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Published inJournal of magnetic resonance (1997) Vol. 201; no. 1; pp. 93 - 99
Main Authors Amor, N, Zaenker, P P, Bluemler, P, Meise, F M, Schreiber, L M, Scholz, A, Schmiedeskamp, J, Spiess, H W, Muennemann, K
Format Journal Article
LanguageEnglish
Published 01.11.2009
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Summary:A technique for continuous production of solutions containing hyperpolarized (129)Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized (129)Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of (129)Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized (129)Xe that has been both dissolved in and outgassed from a carrier liquid in a lung phantom, illustrating its potential for the measurement of lung perfusion and ventilation.
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ISSN:1090-7807
DOI:10.1016/j.jmr.2009.08.004