Linkage Disequilibrium Mapping

Chapter 8 dealt with the origins and evolution of LD and Chapter 9 with cohort and case-control designs for testing associations between a disease and a genetic marker, which could be applied to proposed causal (candidate) genes or to markers not thought to be causal themselves but perhaps in LD wit...

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Bibliographic Details
Published inStatistical Methods in Genetic Epidemiology
Main Author Thomas, Duncan C.
Format Book Chapter
LanguageEnglish
Published New York, NY Oxford University Press 29.01.2004
Oxford University Press, Incorporated
Subjects
Biomathematics and Statistics
Epidemiology & medical statistics
Molecular Biology and Genetics
Public Health
sophisticated
haplotypes
methods
moves
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ISBN019515939X
9780195159394
DOI10.1093/oso/9780195159394.003.0010

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Summary:Chapter 8 dealt with the origins and evolution of LD and Chapter 9 with cohort and case-control designs for testing associations between a disease and a genetic marker, which could be applied to proposed causal (candidate) genes or to markers not thought to be causal themselves but perhaps in LD with a causal gene being sought. We now turn our attention to the latter use of association studies as a means of further localizing the region containing a still undiscovered mutation.
ISBN:019515939X
9780195159394
DOI:10.1093/oso/9780195159394.003.0010