Linkage Analysis

Linkage analysis is the process of determining the approximate chromosomal location of a gene by looking for evidence of cosegregation with other genes whose locations are already known (i.e., marker genes). Cosegregation is a tendency for two or more genes to be inherited together, and hence for in...

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Bibliographic Details
Published inStatistical Methods in Genetic Epidemiology
Main Author Thomas, Duncan C.
Format Book Chapter
LanguageEnglish
Published New York, NY Oxford University Press 29.01.2004
Oxford University Press, Incorporated
Subjects
Biomathematics and Statistics
Epidemiology & medical statistics
Molecular Biology and Genetics
Public Health
general
interested
useful
marker
introduction
Online AccessGet full text
ISBN019515939X
9780195159394
DOI10.1093/oso/9780195159394.003.0007

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Summary:Linkage analysis is the process of determining the approximate chromosomal location of a gene by looking for evidence of cosegregation with other genes whose locations are already known (i.e., marker genes). Cosegregation is a tendency for two or more genes to be inherited together, and hence for individuals with similar phenotypes to share alleles at the marker locus. Gene mapping is a huge topic, for which only a general introduction can be given here. Those interested in more detail can read one of the excellent textbooks by Ott (1999), Haines and Pericak-Vance (1998), or Pawlowitzki et al. (1997). Terwilliger and Ott (1994) provide a useful how-to manual of the mechanics of conducting a linkage analysis, based mainly on the LINKAGE package.
ISBN:019515939X
9780195159394
DOI:10.1093/oso/9780195159394.003.0007