Evidence for anticipation in schizophrenia

Anticipation, or increasing severity of a disorder across successive generations, is a genetic phenomenon with an identified molecular mechanism: expansion of unstable trinucleotide repeat sequences. This study examined anticipation in familial schizophrenia. Three generations of siblines from the a...

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Bibliographic Details
Published inAmerican journal of human genetics Vol. 54; no. 5; pp. 864 - 870
Main Authors BASSETT, A. S, HONER, W. G
Format Journal Article
LanguageEnglish
Published Chicago, IL University of Chicago Press 01.05.1994
Subjects
550900 > Pathology
Adolescent
Adult
Adult and adolescent clinical studies
Age Factors
Aged
Aged, 80 and over
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
BIOLOGY 550400 > Genetics
Child
EXPANSION
Family
family studies
Female
Genes, Dominant
Genetic Linkage
GENETICS
Hospitalization
Humans
Male
man
Medical sciences
MENTAL DISORDERS
Middle Aged
MUTATIONS
PATHOGENESIS
Pedigree
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychotic Disorders - genetics
repeated sequence
Repetitive Sequences, Nucleic Acid
Risk Factors
Schizophrenia
Schizophrenia - epidemiology
Schizophrenia - genetics
Schizophrenia - physiopathology
Survival Analysis
Psychosis
Human
Genetic inheritance
Family study
Schizophrenia
Anticipation
Tandemly repeated sequence
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Summary:Anticipation, or increasing severity of a disorder across successive generations, is a genetic phenomenon with an identified molecular mechanism: expansion of unstable trinucleotide repeat sequences. This study examined anticipation in familial schizophrenia. Three generations of siblines from the affected side of families selected for unilineal, autosomal dominant-like inheritance of schizophrenia were studied (n = 186). Across generations more subjects were hospitalized with psychotic illness (P < .001), at progressively earlier ages (P < .0001), and with increasing severity of illness (P < .0003). The results indicate that anticipation is present in familial schizophrenia. These findings support both an active search for unstable trinucleotide repeat sequences in schizophrenia and reconsideration of the genetic model used for linkage studies in this disorder.
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ISSN:0002-9297
1537-6605