Effect of 6β-methylprednisolone on mouse pregnancy rate

• Published in: Human reproduction (Oxford) Vol. 14; no. 1; pp. 207 - 210
• Main Authors: Velilla, Esther, Grossmann, Mark, Egozcue, Josep, Santaló, Josep
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.01.1999
• Subjects: Animals; Biological and medical sciences; Dose-Response Relationship, Drug; Embryo Implantation - drug effects; Embryo Transfer; Embryonic and Fetal Development - drug effects; Female; Fetal Resorption - epidemiology; Glucocorticoids - pharmacology; Immune System - drug effects; Immunoglobulin G - metabolism; Immunomodulators; Incidence; Medical sciences; Methylprednisolone - pharmacology; Mice; Mice, Inbred Strains; Pharmacology. Drug treatments; Pregnancy; Pregnancy Rate; Pregnancy, Animal - drug effects; methylprednisolone; developmental rate; embryo transfer; immunodepression; implantation rate; Corticosteroid; Steroid hormone; Rodentia; Germinal cell; Methylprednisolone; Zona pellucida; Pregnancy; Embryo transfer; Vertebrata; Immunosuppression; Mammalia; Ovum implantation; Mouse; Immunosuppressive agent; Oocyte; Immune system
• ISSN: 0268-1161; 1460-2350
• DOI: 10.1093/humrep/14.1.207

The aim of this study was to evaluate the effect of methylprednisolone on the pregnancy rate in mice. For this reason, zona pellucida-intact and zona pellucida-free embryos at the blastocyst stage were transferred to recipient mice at day 2.5 of pseudopregnancy. Embryo transfer was performed into non-immunodepressed and immunodepressed groups of recipient mice using 0.3 or 0.6 μg/g of 6β-methylprednisolone. A higher implantation and developmental rate of zona-free embryos transferred to the immunodepressed group of recipients was observed after using the higher dose of methylprednisolone.