Plasma and red cell radioiron following intravenous injection; turpentine abscesses in normal and anemic dogs

Sterile inflammation induced by repeated subcutaneous injections of turpentine in non-anemic, non-iron-deficient dogs, leads to a fall in plasma iron concentration, the development of a moderate anemia, and a marked delay in the uptake by the red blood cells of intravenous radioiron. Similar periods...

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Bibliographic Details
Published inThe Journal of experimental medicine Vol. 90; no. 4; pp. 273 - 282
Main Authors YUILE, C L, BLY, C G
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 01.10.1949
Subjects
Abscess
Anemia
Animals
Blood
Bone Marrow
Dogs
Erythrocytes
Inflammation
Injections, Intravenous
Injections, Subcutaneous
Iron
Plasma
Radioisotopes
Turpentine - toxicity
RADIOACTIVE SUBSTANCES/iron
TURPENTINE/toxicity
BLOOD/iron
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Summary:Sterile inflammation induced by repeated subcutaneous injections of turpentine in non-anemic, non-iron-deficient dogs, leads to a fall in plasma iron concentration, the development of a moderate anemia, and a marked delay in the uptake by the red blood cells of intravenous radioiron. Similar periods of inflammation in anemic, iron-deficient dogs on a diet low in iron cause no increase in the degree of anemia and no inhibition of red blood cell uptake of intravenous radioiron. Radioiron appears only in traces in abscess exudates. Intravenous iron disappearance curves following a single injection are uninfluenced by sterile inflammation in either anemic or non-anemic dogs. The impairment of hemoglobin synthesis caused by inflammation is at most a relative matter, since the anemia that develops is seldom severe or progressive, and since the inhibition can be overcome if the marrow is sufficiently stimulated by the demands of a severe continuing anemia.
ISSN:0022-1007
1540-9538
DOI:10.1084/jem.90.4.273