Radioprotection of hemopoiesis conferred by aqueous extract from chlorococcal algae (Ivastimul) administered to mice before irradiation

In experiments on mice, single i.p. injections of aqueous extract from chlorococcal freshwater algae (Ivastimul) were found to increase their radioresistance. During the same period the number of spleen colony-forming units (CFUs) in the bone marrow and spleen and their proliferation activity increa...

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Bibliographic Details
Published inExperimental hematology Vol. 18; no. 3; p. 234
Main Authors Vacek, A, Rotkovská, D, Bartonícková, A
Format Journal Article
LanguageEnglish
Published Netherlands 01.03.1990
Subjects
Animals
Bone Marrow - radiation effects
Bone Marrow Cells
Cell Division - drug effects
Chlorella
Colony-Forming Units Assay
Colony-Stimulating Factors - blood
Eukaryota - analysis
Female
Gamma Rays
Granulocytes - cytology
Hematopoiesis - radiation effects
Hematopoietic Stem Cells - cytology
Macrophages - cytology
Mice
Mice, Inbred C57BL
Mice, Inbred CBA
Plant Extracts
Radiation-Protective Agents - pharmacology
Spleen - cytology
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Summary:In experiments on mice, single i.p. injections of aqueous extract from chlorococcal freshwater algae (Ivastimul) were found to increase their radioresistance. During the same period the number of spleen colony-forming units (CFUs) in the bone marrow and spleen and their proliferation activity increased. The amount of granulocyte-macrophage colony-forming cells (GM-CFC) in the bone marrow grows and the colony-stimulating activity (CSA) of the blood serum of mice is elevated at an early period after injection of the substance. The recovery of the CFUs and GM-CFC pools in femoral bone marrow after irradiation proceeds at a faster rate in Ivastimul-treated animals than in control groups. The activation of the pool of hemopoietic stem cells and stimulatory effects of Ivastimul on granulocytopoiesis act favorably on the repair of radiation damage and on increased percentage of animals surviving lethal doses of gamma radiation.
ISSN:0301-472X