Syntheses of 24R,25-dihydroxy-[6,19,19-3H]vitamin D3 and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3

24R,25-Dihydroxy-[6,19,19-3H]vitamin D3 with a specific activity of 54 Ci/mmol and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3 with 2.6 deuterium atoms/mol were synthesized in four steps starting from 24R,25-Dihydroxyvitamin D3 via its sulfur dioxide adduct.

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Bibliographic Details
Published inSteroids Vol. 54; no. 2; pp. 145 - 157
Main Authors Yamada, S, Shimizu, M, Fukushima, K, Niimura, K, Maeda, Y
Format Journal Article
LanguageEnglish
Published United States 01.08.1989
Subjects
24,25-Dihydroxyvitamin D 3 - chemical synthesis
550201 - Biochemistry- Tracer Techniques
BASIC BIOLOGICAL SCIENCES
CHEMICAL PREPARATION
DEUTERIUM
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
Isotope Labeling - methods
ISOTOPES
LIGHT NUCLEI
MASS SPECTRA
Mass Spectrometry
NUCLEI
ODD-ODD NUCLEI
SPECTRA
STABLE ISOTOPES
Sulfur Dioxide
SYNTHESIS
TRACER TECHNIQUES
Tritium
VITAMIN D
VITAMINS
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Summary:24R,25-Dihydroxy-[6,19,19-3H]vitamin D3 with a specific activity of 54 Ci/mmol and 24R,25-dihydroxy-[6,19,19-2H]vitamin D3 with 2.6 deuterium atoms/mol were synthesized in four steps starting from 24R,25-Dihydroxyvitamin D3 via its sulfur dioxide adduct.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0039-128X
1878-5867
DOI:10.1016/0039-128X(89)90090-1