Genetic variation at the ApoB 3' HVR, D2S44, and D7S21 loci in the Ewondo Ethnic Group of Cameroon

A sample of the Ewondo population (a Bantu-speaking group of Southern Cameroon) was analyzed for the polymorphism at three tandem repeated DNA loci (ApoB 3[prime] HVR, D2S44, and D7S21). The authors observed a greater number of ApoB 3[prime] HVR alleles (17) and a significantly higher estimated hete...

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Published inAmerican journal of human genetics Vol. 55; no. 1; pp. 168 - 174
Main Authors DESTRO-BISOL, G, PRESCIUTTINI, S, D'ALOJA, E, DOBOSZ, M, SPEDINI, G, PASCALI, V. L
Format Journal Article
LanguageEnglish
Published Chicago, IL University of Chicago Press 01.07.1994
Subjects
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
BIOLOGICAL VARIABILITY
Fundamental and applied biological sciences. Psychology
GENETIC VARIABILITY
Genetics of eukaryotes. Biological and molecular evolution
Human
HUMAN POPULATIONS
MINORITY GROUPS
Population genetics, reproduction patterns
POPULATIONS 550400 > Genetics
Cameroon
Africa
Apolipoprotein B
Human
Statistical test
Population
Method
Tandemly repeated sequence
Population genetics
Ethnic group
Comparative study
Polymorphism
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Summary:A sample of the Ewondo population (a Bantu-speaking group of Southern Cameroon) was analyzed for the polymorphism at three tandem repeated DNA loci (ApoB 3[prime] HVR, D2S44, and D7S21). The authors observed a greater number of ApoB 3[prime] HVR alleles (17) and a significantly higher estimated heterozygosity (.879[+-].011) than in previously surveyed populations, with the exception of U.S. Blacks. The higher genetic variability of Ewondo and U.S. Blacks was also shown by the ApoB 3[prime] HVR allele-frequency spectra. A method for measuring population distances, based on cumulative fragment-size distribution, is described. Interpopulation comparisons for ApoB 3[prime] HVR were carried out by this method and were compared with those obtained by a genetic distance measurement. The two sets of results showed a consistent pattern of population differentiation: the Ewondos and the U.S. Blacks clustered together and were apart from both a Caucasian cluster (Swedes, U.S. Whites, Italians, and Germans) and other well-defined populations (Sikhs of India and Pehuence Indians of Chile). Profile distances were then computed from D2S44 and D7S21 binned data. This analysis indicated a genetic affinity between Ewondos, U.S. Blacks, and Afro-Caribbean Blacks and outlined the genetic diversity between Ewondos, Caucasians, and Asian Indians. 56 refs., 5 figs., 1 tab.
Bibliography:None
ISSN:0002-9297
1537-6605