Dipyridamole 201Tl scintigraphy in the evaluation of prognosis after myocardial infarction

• Published in: Circulation (New York, N.Y.) Vol. 84; no. 3; pp. I132 - I139
• Main Authors: OKADA, R. D, GLOVER, D. K, LEPPO, J. A
• Format: Conference Proceeding Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.09.1991
• Subjects: Aged; BETA DECAY RADIOISOTOPES; Biological and medical sciences; BODY; Cardiology. Vascular system; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; Coronary heart disease; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSIS; DIAGNOSTIC TECHNIQUES; DIAGRAMS; Dipyridamole; DISEASES; DRUGS; ELECTROCARDIOGRAMS; Electrocardiography; ELECTRON CAPTURE RADIOISOTOPES; Female; Follow-Up Studies; HEART; HEAVY NUCLEI; Humans; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; Male; Medical sciences; Middle Aged; MYOCARDIAL INFARCTION; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - physiopathology; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATIENTS; Prognosis; RADIOISOTOPE SCANNING; RADIOISOTOPES; RADIOLOGY AND NUCLEAR MEDICINE; Radionuclide Imaging; SCINTISCANNING; SECONDS LIVING RADIOISOTOPES; SENSITIVITY ANALYSIS; Stroke Volume; THALLIUM 201; THALLIUM ISOTOPES 550601 > Medicine > Unsealed Radionuclides in Diagnostics; Thallium Radioisotopes; Time Factors; VASODILATORS
• ISSN: 0009-7322; 1524-4539

Dipyridamole 201Tl imaging has been proposed as an alternative to exercise ECG testing for the prehospital discharge evaluation of patients recovering from myocardial infarction. The rationale is that many postinfarction patients with exercise-induced ischemia experience later cardiac events, and the sensitivity of predischarge exercise ECG testing in patients with multivessel disease ranges from only 45% to 62%. In addition, several groups of investigators have shown the sensitivity of submaximum exercise 201Tl imaging to be less than ideal. This report summarizes the current status of dipyridamole 201Tl imaging in the period of 1-13 days after myocardial infarction. Although the number of studies performed to date is limited, the following conclusions can be drawn: dipyridamole 201Tl imaging after myocardial infarction was associated with no serious side effects, and those present could be quickly reversed with aminophylline; redistribution with dipyridamole 201Tl images definitely correlates with prognosis after uncomplicated myocardial infarction; dipyridamole 201Tl imaging is definitely useful in patients unable to exercise for a variety of reasons; and future studies are definitely indicated to further define the role of dipyridamole 201Tl imaging for assessing prognosis, especially in those patients undergoing interventional therapy after acute myocardial infarction.