Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease

• Published in: Genomics & informatics Vol. 16; no. 4; pp. e25 - 25
• Main Authors: Avazpour, Niloofar, Hajjari, Mohammadreza, Yazdankhah, Saeed, Sahni, Azita, Foroughmand, Ali Mohammad
• Format: Journal Article
• Language: English
• Published: Korea (South) 한국유전체학회 01.12.2018
• Subjects: 자연과학일반; HOTAIR; coronary artery disease; long noncoding RNA; gene expression
• ISSN: 1598-866X; 2234-0742
• DOI: 10.5808/GI.2018.16.4.e25

Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript play a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated circulating long noncoding RNAs in blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data show that expression of HOTAIR is up-regulated in blood samples of patients with CAD.