蜈蚣 에테르 추출물의 RAW 264.7 cell에서 LPS로 유도된 염증반응 억제 효과

• Published in: 동의생리병리학회지 Vol. 27; no. 1; pp. 78 - 82
• Main Authors: 정호경(Ho Kyung Jung), 조현우(Hyun Woo Cho), 정원석(Won Seok Jung), 최인영(In Young Choi), 조정희(Jung Hee Cho), 정수영(Su Young Jung)
• Format: Journal Article
• Language: Korean
• Published: 한의병리학회 2013
• Subjects: 한의학; Scolopendra morsitans L; COX-2; TNF-α; Nitric oxide; Anti-inflammation
• ISSN: 1738-7698; 2288-2529
• DOI: 10.15188/kjopp.2013.02.27.1.78

It has been reported that Scolopendra morsitans L.(SML) has beneficial effects on human health and diverse diseases. The purpose of this study was to investigate the anti-inflammatory effects of ether extract from Scolopendra morsitans L. on lipopolysaccharide(LPS)-induced inflammatory response. Thus, we examined the inhibitory effect of SML ether fraction on LPS-induced increase of inflammatory mediators(NO, iNOS, COX-2, and IκBα) and pro-inflammatory cytokines(TNF-α) in RAW 264.7 cells. In the present study, SML ether extract itself decreased cell viability in a dose dependent manner(> 100 μg/ml). In addition, LPS increased NO production, iNOS expression and phosphorylation of Iκ-Bα, which were blocked by the treatment of SML ether fraction in a dose dependent manner. Furthermore, the treatment of LPS increased TNF-α production. However, the pretreatment of SML ether fraction prevented the LPS-induced TNF-α production in dose dependant manner. Taken together, our results suggest that SML may be a beneficial drug against inflammatory diseases such as sepsis. KCI Citation Count: 1