Decreased platelet level in peripheral blood of mice by microgravity

It is reported that the stay in the space develop anemia, throbocytopenia, and altered function and structure of red blood cell. The mechanism of these abnormalities was not clarified yet. TPO has been shown to stimulate both megakaryocyte colony growth from marrow progenitor cells and the maturatio...

Full description

Saved in:
Bibliographic Details
Published inUchū seibutsu kagaku Vol. 16; no. 3; pp. 159 - 160
Main Authors Fuse, Akira, Aoki, Yoichiro, Sato, Takeyuki, Sunohara, Masataka, Takeoka, Hajime
Format Journal Article
LanguageEnglish
Published Japan 01.11.2002
Subjects
Animals
Blood Platelets - physiology
Female
Hypergravity
Mice
Mice, Inbred BALB C
Platelet Count
Space Flight
Space life sciences
Thrombocytopenia - etiology
Thrombopoietin - blood
Thrombopoietin - metabolism
Time Factors
Weightlessness - adverse effects
Online AccessGet full text

Cover

More Information
Summary:It is reported that the stay in the space develop anemia, throbocytopenia, and altered function and structure of red blood cell. The mechanism of these abnormalities was not clarified yet. TPO has been shown to stimulate both megakaryocyte colony growth from marrow progenitor cells and the maturation of immature megakaryocyte to form functional platelet. This process include massive cytoskeletal rearrangement, such as proplatelet formation and fragmentation of proplatelet. Our previous reports (Fuse and Sato, 2001, Fuse et al, 2001) showed an inverse relationship between decreased platelet count and increased TPO concentrations in peripheral blood of mouse was induced by parabolic flight (PF). We have studied which gravity change during PF involved this phenomenon.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0914-9201