Tannin–Thioctic Acid Network Hydrogels with Antibacterial and Hydrophobic Properties

• Published in: Fibers and polymers pp. 3373 - 3384
• Main Authors: Xinyi Hu, Que Kong, Rong Li, Change Zhou, Zhiguang Li
• Format: Journal Article
• Language: English
• Published: 한국섬유공학회 01.10.2023
• Subjects: 섬유공학
• ISSN: 1229-9197; 1875-0052
• DOI: 10.1007/s12221-023-00329-y

Making a multifunctional hydrogel-based wound dressing is a long-term research goal. Therefore, it is of great significance to develop an ideal wound dressing with desirable biocompatibility, adhesive property, antibacterial property and simple production. Herein, molecular network crosslinking hydrogels were achieved through the nucleophilic addition of polyphenol-sulfur radical using tannic acid and thioctic acid as matrix. The multifunctional tannic–thioctic acid (TATA) hydrogels with excellent rheological properties were prepared by further modification of antibacterial and hydrophobic properties. The successful cross-linking of the molecules was confirmed by infrared spectroscopy, Raman spectroscopy and energy dispersive X-ray spectroscopy (EDX). Complex hydrogels had certain hydrophobic properties, which can slowly absorb wound tissue fluid and keep the wetness of the wound. In addition, the hydrogel had good rheological, antibacterial and antioxidant properties, and also improved blood clotting effect and biocompatibility. These results indicated that TATA hydrogel had the potential prospect to be used as a novel wound dressing for a wide range of medical applications. KCI Citation Count: 0