항염증 효과 연구를 통한 사향의 수용화 기술 평가

• Published in: KSBB Journal Vol. 35; no. 3; pp. 244 - 250
• Main Authors: 이효성(Hyo Seong Lee), 김용수(Yong Soo Kim), 이경섭(Kyeong-Seob Lee), 한지현(Ji Hyun Han), 이찬용(Chan Yong Lee), 김기광(Kee K. Kim)
• Format: Journal Article
• Language: Korean
• Published: 한국생물공학회 01.09.2020
• Subjects: 생물공학; water-solubilization technology; musk; anti-inflammatory activity
• ISSN: 1225-7117; 2288-8268
• DOI: 10.7841/ksbbj.2020.35.3.244

Musk is a traditional high-grade medical product that has a great anti-inflammatory activity. However, musk is a poorly soluble substance, which is difficult to use in the food and drug field. Therefore, in order to increase the efficacy of musk, research on the water-solubilization of musk is necessary. In this study, we have applied the water-solublization technology to musk and the solubility of musk with water-solubilization technology was compared with the solubility of musk without water-solubilization technology to confirm the water-solubility. Next, we investigated antioxidant efficacy of musk with water-solublization technology and effect of musk with water-solublization technology on antiinflammatory activity using mouse macrophage RAW 264.7 cells. As a result, musk with water-solublization technology showed excellent radical scavenging ability. the mRNA expressions of IL-1β, IL-6, which cytokines released during inflammatory reactions, were repressed and the activity of mouse macrophages increased by treatment of musk with water-solublization technology. In conclusion, these results suggest that water-solublization technology improved the absorption of musk and musk with water-solublization technology can increase musk's antioxidant activity and antiinflammatory activity, which can be used in various fields including the food and drug fields. KCI Citation Count: 0