약용식물의 기능성 성분 분석 및 다양한 생리활성

• Published in: Han'guk Sikp'um Yŏngyang Kwahakhoe chi Vol. 48; no. 12; pp. 1345 - 1351
• Main Authors: 박성익(Seong Ik Park), 황희영(Hee Young Hwang), 김종식(Jong-Sik Kim), 박승우(Seung Woo Park)
• Format: Journal Article
• Language: Korean
• Published: 한국식품영양과학회 01.12.2019
• Subjects: 식품과학; anti-high blood pressure; anti-oxidation; medicinal herbs; functional components; anti-diabetes
• ISSN: 1226-3311; 2288-5978
• DOI: 10.3746/jkfn.2019.48.12.1345

본 연구는 11종의 약용식물의 메탄올 추출물을 제조하고 이들의 기능성 성분 및 항산화, 항당뇨, 항고혈압 등 다양한 생리활성을 분석하였다. 총 폴리페놀 함량은 야관문(102.7 mg GAE/g), 오가피(98.0 mg GAE/g), 어성초(66.1 mg GAE/ g) 순으로 높았으며, 총 플라보노이드 함량은 야관문(62.8 mg QE/g), 어성초(23.6 mg QE/g) 오가피(16.6 mg QE/g) 순으로 높았다. DPPH와 ABTS 분석 결과는 오가피(87.9%, 90.9%), 어성초(83.1%, 87.9%), 야관문(79.3, 85.8%) 순으로 높았다. FRAP assay 결과에서는 야관문(169.5 mg TE/ g), 오가피(165.5 mg TE/g), 해동피(62.4 mg TE/g) 순으로 높았다. ACE 저해 활성은 구기자(19.2%), 해동피(16.8 %), 야관문(13.5%) 순으로 높았다. α-Glucosidase 저해 활성은 야관문(93.7%), 산수유(50.9%), 천궁(28.9%) 순으로 높았다. 본 논문의 연구 결과는 11종의 약용식물의 기능성 성분 분석 및 다양한 생리활성 연구에 도움이 될 것으로 사료된다. This study prepared the methanol extracts from 11 different kinds of Korean medicinal herbs and analyzed their functional components and various biological activities including anti-oxidation, anti-diabetes and anti-high blood pressure activities. The total polyphenol contents were higher in the order of Lespedeza cuneata (102.7 mg gallic acid equivalents (GAE)/g), Eleutherococcus senticosus (98.0 mg GAE/g), and Houttuynia cordata (66.1 mg GAE/g). The total flavonoid contents were higher in the order of L. cuneata (62.8 mg quercetin equivalents (QE)/g), H. cordata (23.6 mg QE/g), and E. senticosus (16.6 mg QE/g). The 1,1-diphenyl-2-picrylhydrazyl and 2,2’-azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) radical scavenging activities were higher in the order of E. senticosus (87.9% and 90.9%, respectively), H. cordata (83.1% and 87.9%, respectively), and L. cuneata (79.3% and 85.8%, respectively). The results of ferrous reducing antioxidative power assay were higher in the order of L. cuneata (169.5 mg Trolox equivalents (TE)/g), E. senticosus (165.5 mg TE/g), and Kalopanax pictus (62.4 mg TE/g). The results of angiotensin converting enzyme inhibition assay were higher in the order of Lycium chinense (19.2%), K. pictus (16.8%), and L. cuneata (13.5%). The results of α-glucosidase inhibition assay were higher in the order of L. cuneata (93.7%), Cornus officinalis (50.9%), and Cnidium officinale (28.9%). Overall, these results will help to analyze functional components and to investigate various biological effects of these traditional Korean medicinal herbs. KCI Citation Count: 1